Wednesday, Sept. 05, 2007
Thursday, Sept. 06, 2007
| Time |
Program and Speaker |
Title of presentation |
| from 8:00 |
Registration |
| 9:00 – 12:40 |
Session I : Infectious diseases I (Chair: Rudolf Ladenstein) |
| 9:00 – 9:30 |
Gabriel Waksman (London) |
The chaperone-usher pathway of pilus biogenesis: structural basis of the assembly process and of host recognition |
| 9:30 – 9:50 |
Deshmukh Gopaul (Paris) |
Integron integrases: DNA specificity and bacterial adaptation |
| 9:50 – 10:10 |
Steven Johnson (Oxford) |
Elucidation of the structural mechanisms behind signal transduction in the bacterial type III secretion system |
| 10:10 – 10:40 |
C. Erec Stebbins (New York) |
Bacterial modulation of host biochemistry |
| 10:40 – 11:10 |
coffee break |
| 11:10 – 11:30 |
Gunther Kern (Waltham) |
Biophysical approaches to target-based discovery of novel antibacterials |
| 11:30 – 11:50 |
Hartmut Niemann (Bielefeld) |
Crystal structure of the human receptor tyrosine kinase Met in complex with the Listeria monocytogenes invasion protein InlB |
| 11:50 – 12:20 |
Stephen Matthews (London) |
Atomic resolution basis for host cell recognition by apicomplexan parasites and pathogenic bacteria |
| 12:30 –
14:30 |
lunch break |
| 14:30 – 17:30 |
Session II : Infectious diseases II (Chair: Manfred Weiss) |
| 14:30 – 15:00 |
Rolf Hilgenfeld (Lübeck) |
Proteases as targets for new antiinfectives |
| 15:00 – 15:20 |
Young Do Kwon (Bethesda) |
Structure of HIV-1 gp120 in complex with CD4-binding-site antibody F105 |
| 15:20 – 15:50 |
Dennis Bamford (Helsinki) |
Capsid centric attempt to organize the virosphere using structures: relatedness of viruses from bacteriophages to viruses infecting humans |
| 15:50 – 16:20 |
coffee break |
| 16:20 – 16:40 |
Eloise Mastrangelo (Milano) |
Structure and activity of Kunjin virus NS3 helicase domain |
| 16:40 – 17:00 |
Christian Wiesmann (San Francisco) |
Structures of C3b and C3c in complex with selective inhibitors of the alternative pathway convertases |
| 17:00 – 17:30 |
Winfried Weissenhorn (Grenoble) |
Negative strand RNA virus nucleocapsid structure and function |
| 17:30 – 18:00 |
Meeting of the GBM study group "Structural Biology" |
| 18:00 – 20:00 |
Poster Session part I / A-K |
| 20:00 – 22:00 |
Informal conference buffet dinner in Foyer |
Friday, Sept. 07, 2007
| Time |
Program and Speaker |
Title of presentation |
| 9:00 – 12:00 |
Session III : Protein Misfolding Diseases (Chair: HolgerStark) |
| 9:00 – 9:30 |
Roland Riek (La Jolla / Zürich) |
Structural studies of protein aggregates |
| 9:30 – 9:55 |
Markus Fändrich (Jena) |
Structure and conformational heterogeneity of amyloid fibrils explored with cryo microscopy |
| 9:50 – 10:10 |
Luigi Vitagliano (Naples) |
Structure and stability of amyloid-like aggregates investigated by molecular dynamics |
| 10:10 – 10:40 |
Jens Radzimanowski (Heidelberg) |
The crystal structure of the Fe65-PTB1 domain reveals a phosphorylation dependence of amyloid precursor protein signalling |
| 10:40 – 11:10 |
coffee break |
| 11:10 – 11:30 |
Christian Betzel (Hamburg) |
Structural investigations of prion protein aggregation in vitro |
| 11:30 – 12:00 |
David Eisenberg (Los Angeles) |
Atomic Structures of Amyloid Fibrils |
| 12:00 – 14:00 |
lunch break |
| 14:00 – 17:30 |
Session IV Cancer (Chair: P. Cramer) |
| 14:00 – 14:30 |
Alan Fersht (Cambridge) |
The tumour suppressor p53: structure, function-rescue |
| 14:30 – 14:50 |
Guillermo Montoya (Madrid) |
Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in centrosomal localization |
| 14:50 – 15:10 |
Holger Rehmann (Utrecht) |
Structural basis of the regulation of Epac by cAMP |
| 15:10 – 15:40 |
Joseph Schlessinger (New Haven) |
Cell signaling by receptor tyrosine kinases: from bench to bedside |
| 15:40 – 16:10 |
coffee break |
| 16:10 – 16:40 |
Alfred Wittinghofer (Dortmund) |
The GTPase reaction of Ras as an anticancer target |
| 16:40 – 17:00 |
Claus Kuhn (Munich) |
Functional architecture of RNA polymerase I based on an integrated structural biology approach |
| 17:00 – 17:30 |
Titia Sixma (Amsterdam) |
Modulation of the enzymatic activity of E2 and E3 in ubiquitin conjugation |
| 17:30 – 19:30 |
Poster Session part II / L-Z |
| from 20:00 |
Conference Dinner (in Griesbräu brewery) |
Saturday, Sept. 08, 2007
| Time |
Program and Speaker |
Title of presentation |
| 9:00 – 12:40 |
Session V : Metabolic and Other Diseases (Chair: Yves Muller) |
| 9:00 – 9:30 |
Michael Lawrence (Victoria) |
First insights into the structure of the insulin receptor ectodomain homodimer |
| 9:30 – 9:50 |
Günter Fritz (Konstanz) |
Structures of RAGE ligand binding domain and RAGE ligands provide insights into receptor activation |
| 9:50 – 10:10 |
Armin Ruf (Basel) |
X-ray structure guided design and synthesis of potent and balanced PPAR-alpha/gamma dual agonists |
| 10:10 – 10:40 |
Annalisa Pastore (London) |
|
| 10:40 – 11:10 |
coffee break |
| 11:10 – 11:30 |
Antti Haapalainen (Oulu) |
Structural enzymological studies on the human mitochondrial acetoacetyl-CoA thiolase (T2) |
| 11:30 – 11:50 |
Markus Wahl (Göttingen) |
Structural analyses of pre-mRNA splicing factors revealing links to autosomal dominant forms of Retinis Pigmentosa |
| 11:50 – 12:10 |
Ryota Kuroki (Ibaraki) |
Homodimeric crossover structure of the human granulocyte colony stimulating factor receptor signaling complex |
| 12:10 – 12:40 |
Roger Williams (Cambridge) |
Phosphoinotide 3-kinase dependent sorting to lysosomes |
| 12:40 – 12:45 |
Concluding remarks (Dirk Heinz) |
| 12:45 |
End of meeting |
| from 13:00 |
Farewell and departure |
| from 14:30 |
optional: Sightseeing tour (Linderhof Palace of king Ludwig II) |
