Program and Schedule 2024

September 18, 2024 (Wednesday)

16:00 

Registration open

17:00

Informal get-together, dinner buffet

19:00 

Conference Opening - Welcome Note

19:15

The Murnau Lecture 2024
Werner Kühlbrandt (MPI Frankfurt) - Structure of ATP synthase and complex I from and in mitochondria - GBM Keynote Lecture

20:15

Beer and snacks

 

September 19, 2024 (Thursday)

8:30

Registration open

Session 1

Dynamic Processes  Chair: Janosch Hennig

09:00

Katja Petzold - What do microRNAs and ribosomes have in common? - GBM Lecture

09:40

Jessica Schmuck - NMR spectroscopy of self-hydrolysing NMR

09:55

Philipp Neudecker - Transverse Relaxation Optimized Spectroscopy in the Presence of Chemical Exchange at 1.2 GHz 

10:10                  Till Rudack - 

Beyond static structures: Integrating cryo-EM, NMR and MD simulations to create complete struc tural dynamic models of macromolecular machines 

10:25

Coffee break

10:55

Claus Seidel - Integrative dynamic structural biology with multi-modal fluorescence spectroscopy:  Making structural and associated kinetic information accessible - GBM Lecture

11:35

Benedikt Kuhn - Structure and function of the multi-functional solute carrier SLC26A11 

11:50

Anastasiia Chaban - Real-time tracking of early ribosomal RNA transcription and processing 

12:05

Georgios Skiniotis - Time-resolved cryoEM of G protein activation by a GPCR 

12:20

Lunch with poster session and exhibition (even numbered posters)

Session 2

In situ Structural Biology Chair: Cristina Paulino

14:00

Julia Mahamid - Enabling discovery by in-cell structural biology - GBM Lecture

14:40

Mareike Jordan - LEM2-ESCRT filaments form a diffusion barrier during nuclear envelope reformation 

14:55

Stefan Raunser - Unlocking the secrets of heart muscle structure - GBM Lecture

15:35

Coffee break

Session 3

Current and future of X-ray Crystallography Chair: Oliver Einsle

16:00

Thomas Schneider - MX -Quo vadis? - GBM Lecture

16:40

Kim Bartels - SPITROBOT-2: 4D Crystallography at Double the Speed, Half the Effort 

16:55

Janina Gerber - Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease 

17:10 Sophie Korn - 

A core network in the SARS-CoV-2 Nucleocapsid NTD orchestrates RNA recognition 

17:25

Business meeting for GBM members (ca. 20 min),
Poster session (odd numbered posters)

18:30

Dinner buffet with poster session and exhibition

 

September 20, 2024 (Friday)

Session 4

Integrative Structural Biology & cryo-EM | Chair: Irmgard Sinning

09:00

Elena Seiradake - Structural switches  direct neuronal migration in the developing cortex - GBM Lecture

09:40

Andreas Schlundt - An integrated approach to deconvolute a full-length mRNA 3’UTR and its interaction with a multi-domain RNA-binding protein 

09:55

Yasmine Damayanti - A disease-causing mutation in the disordered TRPV4 N-terminus modulates lipid-dependent chan nel activity 

10:10 Simone Heber - Reconstitution of oskar RNA transport elucidates the mechanisms behind RNP remodeling and motor-switching 

10:25

Coffee break

10:55

Sebastian Hiller - The Functional Cycle of Hsp70 Chaperone - GBM Lecture

11:35

Patricia Rothe - Mechanism for the initiation of spliceosome disassembly 

11:50

Vladimir Arinkin - Structures of the Sleeping Beauty transpososome during excision and integration 

12:05          Henriette Ebel - 

Deciphering molecular details of the herpes simplex virus 1 fusion machinery 

12:20

Lunch with poster session and exhibition (all posters)

13:30

Free afternoon

Optional: Guided sightseeing tour

Session 5

AI-supported Structural Biology & Method Development | Chair: Till Rudack

16:30

Roberto Covino - From Pixels to Bayesian Posteriors: Fast Molecular Conformation Estimation from Cryo-EM with simulation-based inference - GBM Lecture

17:10

Sergio Cruz - Towards modeling cellular environments: Bridging cryo-electron tomography and simulations with high confidence 3D template matching 

17:25

Thermofisher - Deniz Ugular - Accelerating Cryo-EM Structure-Based Drug Design with Glacios 2 and Smart EPU 

17:37 CryoCloud - Robert Engelmeier - 

Towards automating cryo-EM data analysis: overcoming challenges of particle localiza tion & preferred orientation 

17:50

Coffee break

18:20

Burkhard Rost - Artificial Intelligence deciphers the code of life written in proteins? - GBM Lecture

19:00

Sören von Bülow - Prediction of phase separation propensities of disordered proteins from sequence 

19:15

Miriam Weber - Simplified High-Pressure Freezing Workflow in Autogrids 

19:30

Christian Hanke - Generating FRET-based integrative structural models and depositing them together with kinetic in formation 

19:45 Walk to Brauhaus Griesbräu

20:15

Conference dinner at Brauhaus Griesbräu, Murnau

 

September 21, 2024 (Saturday)

Session 6

Complementary methods  | Chair: Andreas Schlundt

09:00

Jörg Standfuss - Photopharmacology the movie - Drug release from tubulin at atomic resolution and fourteen orders of magnitude in time - GBM Lecture

09:40

Franziska Elsässer - A structural proteomics approach captures protein structure dynamics and biomolecular condensation in living cells 

09:55

Olivier Duss - Tracking assembly, function and coupling of single active protein-RNA complexes in real-time - GBM Lecture

10:35 Agata Misiaszek - 

Towards long-term imaging of single mRNAs and associated with them translation factors 

10:50

Coffee break

Session 7 More Amazing Structural Biology  | Chair: Milton Stubbs

11:20

Bettina Böttcher - Lymphostatin: Structure of a nontoxic Toxin 

11:35

Esther Hudina - Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies 

11:50 Komal Soni - 

Structure of an aberrant spliceosome intermediate on its way to disassembly 

12:05 George Broutzakis - 

High-resolution structures of the UapA elevator-type purine transporter rationalize the importance of the cytosolic N-terminus in trafficking and transport activity 

12:20 Mariya Lazarova - 

A phylogenetic determinant of conformational plasticity affects antibiotic transport by RND multi drug efflux pumps 

12:35

Closing remarks, poster award ceremony and end of meeting